The molecular bases of the versatile functions of Rho-like GTPases are still unknown.Small domains that bind Cdc42p- and/or Rho-like small GTPases.Also known as the Cdc42/Rac interactive binding (CRIB). The Cdc42/Rac interactive binding (CRIB) region has been shown to inhibit transcriptional activation and cell transformation mediated by the Ras-Rac pathway [<cite idref="PUB00001706"/>]. In fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating [<cite idref="PUB00001277"/>]. PAK-box/P21-Rho-binding